Vaccines are invaluable in ensuring the protection of our species against constantly evolving,
dangerous pathogens that threaten the human population. The vaccination strategy however, has
been largely unchanged for the two centuries, using inactivated pathogenic material to our immune
systems called adjuvants to get our body to recognize the material and develop an immunity to them.
This strategy has many issues. Different people react at different levels to the many components in
the vaccines, potentially causing harmful side effects. Also, some disease-causing pathogens are
complex and mutate quickly, making an inactivated version too nonspecific to create a protective
response. To combat this, very specific subunits or portions of a pathogen can be used as vaccines to enable much more control over what aspect of a pathogen our body is exposed to and taught to
respond to. These subunits offer more safety, but they are not good at inducing a strong immune
response.
My project seeks to increase the immune response to these subunit vaccines by forcing them into
nanoclusters that look bigger and more foreign to our immune cells. This causes them to be
processed more like a pathogen and induces a stronger immune response. By using only the
subunits that we want the body to develop an immunity to as the building blocks of the material, we
increase the development of protection against a very specific part of a pathogen. When dealing with
many different diseases with many different subunits, this allowed more safety and control over what
we administer to patients. This nanocluster method has shown improvements in inducing immune cell
response to subunit vaccine components. This subunit nanocluster delivery system has the potential
to make safer, more protective vaccines for the wide range of diseases that have evolved to threaten
us today.