Arbitration between Actions and Habits: Cortical Regulators and the Influence of Cocaine - Shannon Gourley

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Selecting actions based on their consequences is essential to day-to-day function and yet, is impaired in neuropsychiatric diseases like addiction. Goal-directed action selection likely requires the coordinated output of multiple prefrontal cortical structures, but mechanistic factors are still being identified. I will focus on the neurotrophin BDNF in the orbital prefrontal cortex and PI3-kinase in the medial prefrontal cortex, providing evidence that they are key molecular mechanisms by which the brain coordinates goal-directed action. These findings serve as a platform from which to improve goal-directed action selection following developmental cocaine.

https://mediaspace.gatech.edu/media/gourley/1_in1yurd7

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Arbitration between Actions and Habits: Cortical Regulators and the Influence of Cocaine - Shannon Gourley

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