Recent advances in neurotechnology for basic science research and healthcare have created new and exciting opportunities to interface with our nervous system.  Deep brain stimulation (DBS) is one such technology that has enabled numerous people living with movement disorders reclaim control over their motor function. A deeper understanding of the neural pathways and physiological mechanisms underlying DBS therapy continues to be critically important to improve efficacy and decrease variability of the treatment.  This seminar will first highlight our preclinical efforts to understand how modulating neural pathways with DBS affects information encoding within and external to the basal ganglia and in turn how that relates to changes in motor signs of Parkinson’s disease. The seminar will also cover how subject-specific computational modeling and optimization theory can enable prospective identification of therapeutic DBS settings in individuals with Parkinson’s disease.