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Resilience or vulnerability to stress-related emotional disorders is governed in part by early-life experiences. Early-life adversity can profoundly impact an individual’s risk for depression,…

Hand dexterity is the hallmark of human skill and intelligence. From Pablo Casals’ sublime cello playing to the mundane task of tying one’s shoelace, the level of dexterity in humans…

Consciousness is, for each of us, the presence of subjective experience. Without consciousness there is no world, no self: there is nothing at all. In this talk, I will illustrate how the framework…

The view of human brain function has drastically shifted over the last decade, owing to the observation that the majority of brain activity is intrinsic rather than driven by external stimuli or…

Over the last 20 years, numerous human brain imaging studies related to motor control have identified left hemispheric parietofrontal activity as central to motor planning and execution for complex…

Through the combination of in vivo optical imaging and chronic expression of genetically encoded calcium indicators it is now feasible to directly 'watch' brain activity patterns related to…

Our perception of music, speech and the surrounding soundscape all originate from patterns of vibrations in the cochlea. To encode these high-speed vibrations, evolutionary pressures designed an…

Posttraumatic stress disorder (PTSD) is a serious psychiatric condition that affects 6-8% of the general population and 30-46% of military or highly traumatized urban populations. Different…

Animal behavior is a key component of biological adaptations, where fitness relies on the ability to find mates, acquire food, and avoid predation. Variation in the availability of key ecological…

Perceptual sensitivity varies from moment to moment. One potential source of this variability is spontaneous fluctuations in cortical activity that can travel as waves. Spontaneous travelling waves…

Our sensory pathways extract information from the complex world within which we live, and help us to perceive relevant inputs, make decisions, and take action. Our laboratory has extensively…

Muscle spindles richly innervate muscles in vertebrates, providing critical sensory information about the body’s mechanical interactions with the environment necessary for neural control of…

Survival requires proper association of reward outcomes to choices and actions that precede them. To learn successfully, however, the brain must constantly adjust how it incorporates each reward…

Many decisions arise through an accumulation of evidence to a terminating threshold. The process provides a unified account of the choice (e.g., accuracy) and the amount of time taken to complete it.…