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Flies are among nature’s most agile flying creatures. This exquisite maneuverability is due in part to their possession of specialized mechanosensory organs known as the halteres. The halteres…

Deep brain stimulation (DBS) is an established clinical therapy for the treatment of movement disorders, and evolving to become a viable clinical option for the treatment of psychiatric disorders. In…

How do we explore and learn about our world? In nature, animals do not passively await stimuli, as they typically must do in the laboratory. Instead, they actively seek out sensory…

Functional neuroimaging and electrophysiological techniques, such as functional magnetic resonance imaging (fMRI) as well as electro- and magnetoencephalography (EEG/MEG), serve well to study…

Our group develops new light-based technologies for in vivo imaging and sensing of the brain and eye, with the goal of understanding what goes wrong in disease and detecting it earlier. Starting with…

Cortically controlled neuroprostheses have long been posited as the “holy grail” for intracortical brain-machine interfaces (BMIs). The efficacy of BMIs has advanced to the point where a…

Predictive coding is a theory of brain function that assumes the brain contains an internal model of the world, which constantly generates predictions about our environment, and updates the…

There is no doubt that cognition and intelligence are the results of neural activity - but how, exactly? How do molecules, neurons, and synapses give rise to reasoning, language, plans, stories, art,…

Humans are unique among animals not only in their shared cognitive capacities but also in their remarkable adaptability to diverse environments. Studies with people born blind provide insights into…

Spontaneous animal behavior is built from action modules that are concatenated by the brain into sequences. However, the neural mechanisms that shape the composition of self-motivated behavior…

Proprioception, the sense of self-movement and body position, is critical for the effective control of motor behavior. Humans lacking proprioceptive feedback, such as patients with peripheral nerve…

Assembly of inhibitory and excitatory neurons into networks represents a critical period in the development of the cerebral cortex during which early principles of circuit formation and function are…

Despite breathtaking advances in ML, and in our understanding of the brain at the level of neurons, synapses, and neural circuits, we lack a satisfactory explanation for the brain's performance…

Animals constantly modify their behavior through experience. Flexible behavior is key to our ability to adapt to the ever-changing environment. My laboratory is interested in studying the activity of…