Masayoshi Tomizuka joined the Mechanical Engineering Department of UC Berkeley in 1974 after obtaining a PhD from MIT in the same year. It was an exciting time for someone in the field of dynamic systems and control. The 1960’s – 1970’s was the period when the state space control theories blossomed such as maximum principle, dynamic programming, Lyapunov stability, Kalman filtering, Linear Quadratic Gaussian Control and stability based adaptive control theory. At the same time, computer/information technology has made phenomenal advances during the period. At MIT Tomizuka used IBM1130 (with a card reader and printer) and a PDP-8 mini-computer. When he joined UC Berkeley, the campus mainframe computer was a CDC (Control Data Corporation) 6000 series computer, and the lab computer was PDP-7, which was upgraded to PDP-11, LSI-11, etc. The control program at Berkeley covered from both theory to implementation, and it was followed by many other schools. The1970’s was the time when a new generation of mechanical systems showed up; IBM introduced the Winchester Hard Disk Drive in 1973 and the FANUC Corporation was established in 1972. Tomizuka's laboratory, Mechanical Systems Control (MSC) Laboratory, naturally evolved to a group to study both mathematical and implementation aspects of controls. The current research emphasis of the MSC Laboratory is on intelligent industrial robots and autonomous driving. Several representative current projects will be introduced.